Carboxylic acids and derivatives
Apexbio Technology LLC GSK1349572 sodiuM salt 1051375-19-9 50mg
GSK1349572 sodium salt (CAS 1051375-19-9) is a small-molecule inhibitor targeting HIV integrase It is designed to inhibit the integrase-mediated strand transfer process thereby blocking the integration of viral DNA into the host genome GSK1349572 sodium salt exerts its biological activity primarily through interaction with the enzyme s two-metal ion catalytic site inhibiting strand transfer In in vitro studies GSK1349572 sodium salt demonstrates potent antiviral inhibition with a protein-adjusted IC50 of approximately 38 nM in the presence of 100% human serum Based on these pharmacological properties GSK1349572 sodium salt holds research potential in antiviral studies evaluation of resistance profiles and drug development of integrase inhibitors for HIV therapy
Medchemexpress LLC SMD-3040 (formate) | 3033109-92-8 | 99.8% | 989.2 g/mol | C53H68N10O7S | 10 MG
SMD-3040 formate is a research-grade PROTAC degrader that selectively targets SMARCA2, producing robust degradation (DC50: 12 nM; Dmax: 91%) and inhibiting proliferation of certain tumor cell lines. It has demonstrated in vivo antitumor activity in xenograft models and is supplied as the formate salt for laboratory research (not for human use).
- Potent SMARCA2 degradation (DC50: 12 nM; Dmax: 91%).
- Demonstrated in vivo antitumor activity in xenograft models.
- High chemical purity (~99.8%).
- Supplied as the formate salt for laboratory use.
- Suitable for cell-based and in vivo pharmacology studies (research use only).
- Recommended storage: 4°C sealed; in solvent: -80°C (6 months), -20°C (1 month).
eMolecules 1067-33-0 | Ambeed | Dibutyltin diacetate | 25g | 742299394 | A158384 | MFCD00008697 | 351.03 | C12H24O4Sn
Ambeed | 4-Bromo-23-difluoroaniline | 250mg | 521396355 | A114207 | 112279-72-8 | MFCD09030643 | 208.006 | C6H4BrF2N
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Pfanstiehl Inc Dramamine Active EDGT (D-135) 1kg pack API, active pharmaceutical ingredient- CAS: 523-87-5
Dramamine Active EDGT (D-135) 1kg pack API, active pharmaceutical ingredient- CAS: 523-87-5
![eMolecules 13429-27-1 | Potassiummyristate | Ambeed | MFCD00152765 | 266.466 | C14H27KO2 | 95.000 | [K+].CCCCCCCCCCCCCC([O-])=O | 5g | 714085493](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502432107.PNG-250.jpg)
eMolecules 13429-27-1 | Potassiummyristate | Ambeed | MFCD00152765 | 266.466 | C14H27KO2 | 95.000 | [K+].CCCCCCCCCCCCCC([O-])=O | 5g | 714085493
Potassiummyristate | Ambeed | 13429-27-1 | MFCD00152765 | 266.466 | C14H27KO2 | 95.000 | [K+].CCCCCCCCCCCCCC([O-])=O | 5g | 714085493
=O | 1g | 495881470](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502167988.JPG-250.jpg)
eMolecules 96916-42-6 | Isopropenyl p-nitrophenyl carbonate | Synthonix - Stock | MFCD27935132 | 223.184 | C10H9NO5 | 95.000 | CC(=C)OC(=O)Oc1ccc(cc1)[N+]([O-])=O | 1g | 495881470
Isopropenyl p-nitrophenyl carbonate | Synthonix - Stock | 96916-42-6 | MFCD27935132 | 223.184 | C10H9NO5 | 95.000 | CC(=C)OC(=O)Oc1ccc(cc1)[N+]([O-])=O | 1g | 495881470
Selleck Chemical LLC Dimethindene maleate-E1796-1G
Dimethindene maleate is a selective antagonist of histamine H1 and exhibits antihistamine effects It suppresses the cromakalim-induced/glibenclamide-sensitive K currents in a concentration-dependent and reversible manner
TARGETMOL CHEMICALS INC Trimipramine maleate 500MG
Also available in 1 mL, 50 mg, 100 mg, 200 mg and bulk. Please contact Fisher for quotes. Trimipramine maleate (Surmontil maleate) appears to inhibit serotonin transport and norepinephrine uptake by nerve terminals. This increases available norepinephrine or serotonin and prolongs its action. Trimipramine Maleate is the maleate salt form of trimipramine, a tricyclic secondary amine of the dibenzazepine class, with an antidepressant property. Purity 98.02%
Medchemexpress LLC Edonerpic (maleate) | 519187-97-4 | 99.8% | 407.48 | 500 MG
Edonerpic maleate is a novel neurotrophic agent that inhibits amyloid-β peptides (Aβ). Supplied as a white to off-white solid, it has a high purity of 99.79%. In vitro studies show it preserves cortical neurons, prevents oxidative stress-induced neuronal death, and promotes neurite outgrowth. In vivo research indicates it ameliorates deficits in adult neurogenesis and spatial memory in amyloid-beta peptide-infused rats.
- Neurotrophic agent
- Amyloid-β inhibition
- Neuronal protection: preserves cortical neurons in the presence of Aβ(1-42), prevents oxidative stress-induced neuronal death, and inhibits GSH reduction
- Promotes neurite outgrowth: significantly enhances neurite length in hippocampal slices
- Cognitive and neurogenesis improvement: ameliorates deficits in adult neurogenesis and spatial memory in rats infused with amyloid-beta peptide
- High purity: 99.79%
Medchemexpress LLC PD-168077 maleate | 630117-19-0 | 99.6% | 450.49 | 50 MG
PD-168077 maleate is a selective dopamine D4 receptor agonist with a Ki of 9 nM. It exhibits high selectivity over other D2-like and D1-like receptor family members, as well as α1, α2, 5-HT1A, and 5-HT2A receptors. This compound shows intrinsic activity at the D4 receptor, inhibiting forskolin-stimulated cAMP accumulation or stimulating [3H]thymidine uptake in CHO cells expressing the human D4 receptor. In vivo, PD-168077 dose-dependently induces locomotion.
- Selective dopamine D4 receptor agonist
- Exhibits high selectivity over other D2-like, D1-like, α1, α2, 5-HT1A, and 5-HT2A receptors
- Shows intrinsic activity at the D4 receptor
- Induces locomotion in vivo